Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

456
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
456
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

422
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
422
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

642
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
642
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.3K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems.

Cell systems·2025
Same author

Microfluidic Production of Ultrathin, Handleable Collagen Sheets Exhibiting Toe-heel Tensile Behavior.

Advanced materials technologies·2025
Same author

Targeting the P-selectin/PSGL-1 pathway: discovery of disease-modifying therapeutics for disorders of thromboinflammation.

Blood vessels, thrombosis & hemostasis·2025
Same author

Self-assembling protein nanoparticles for cytosolic delivery of nucleic acids and proteins.

Nature biotechnology·2025
Same author

Synthesis of Sulfonated Peptides Using a Trifluoromethyltoluene-Protected Amino Acid.

The Journal of organic chemistry·2025
Same author

Intact quantitation and evaluation of a PEG-glycosulfopeptide as a therapeutic P-selectin antagonist.

RSC advances·2024

Related Experiment Video

Updated: Mar 19, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.3K

Simulated thrombin responses in venous valves.

E Victoria Dydek1, Elliot L Chaikof2

  • 1Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.

Journal of Vascular Surgery. Venous and Lymphatic Disorders
|June 19, 2016
PubMed
Summary
This summary is machine-generated.

Venous thromboembolism risk increases with tissue factor (TF) near venous valves. Recirculating flow near open valves amplifies thrombin generation, even with TF downstream, highlighting a new mechanism for clot formation.

More Related Videos

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
06:44

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

10.6K
Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis
06:03

Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis

Published on: July 12, 2011

17.8K

Related Experiment Videos

Last Updated: Mar 19, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.3K
Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
06:44

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

10.6K
Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis
06:03

Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis

Published on: July 12, 2011

17.8K

Area of Science:

  • Biomedical Engineering
  • Computational Fluid Dynamics
  • Hematology

Background:

  • Venous thromboembolism (VTE) often involves thrombi forming in venous valves due to altered blood flow.
  • Hypoxia-induced tissue factor (TF) expression is a primary suspected cause of thrombus formation.
  • Numerical simulations can model complex coagulation dynamics under non-uniform flow conditions.

Purpose of the Study:

  • To investigate thrombin formation in venous valves using numerical simulations.
  • To analyze the impact of TF position on thrombin generation within disturbed flow induced by an open venous valve.

Main Methods:

  • A computational model simulating hemodynamics, kinetics, and transport of 22 biochemical species was employed.
  • Simulations incorporated disturbed flow from an open venous valve.
  • Three distinct TF positions downstream of the valve opening were analyzed.

Main Results:

  • The critical TF amount for initiating thrombosis decreased by up to 80% when TF was under recirculating flow regions near the valve opening.
  • Thrombin generation occurred within the valve pocket due to increased surface area and recirculating hemodynamics, even with TF downstream of the valve.
  • This suggests a mechanism for thrombus formation independent of direct valve damage.

Conclusions:

  • Recirculating hemodynamics and prothrombotic surface reactions near venous valves offer a mechanism for thrombus formation.
  • This mechanism does not necessitate direct valve damage or dysfunction.
  • Computational modeling provides insights into VTE pathogenesis in venous valves.