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Related Experiment Video

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A Murine Tail Lymphedema Model
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Angiosarcoma after excisional surgery for chronic lymphedema.

Jin Hyun Joh1, Byung-Boong Lee2, Young Soo Chun3

  • 1Department of Surgery, Kyung Hee University School of Medicine, Seoul, Korea.

Journal of Vascular Surgery. Venous and Lymphatic Disorders
|June 19, 2016
PubMed
Summary

Angiosarcoma, a rare cancer originating from endothelial cells, can develop after surgery for chronic lymphedema. This case highlights the aggressive nature of post-surgical angiosarcoma, even with treatment.

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Angiosarcoma is a rare soft tissue sarcoma originating from endothelial cells.
  • It can arise from lymphatic (lymphangiosarcoma) or blood vessel (hemangiosarcoma) endothelium.
  • Chronic lymphedema is a known risk factor for angiosarcoma development.

Observation:

  • This report details a case of angiosarcoma developing 15 months post-excision surgery for lymphedema.
  • The patient underwent radical surgery and adjuvant chemoradiotherapy.
  • Despite aggressive treatment, the patient developed multiple lung metastases and pleural effusion.

Findings:

  • Post-surgical angiosarcoma in the context of lymphedema can be highly aggressive.
  • Adjuvant chemoradiotherapy may not prevent distant metastases in these cases.

Implications:

  • This case underscores the importance of vigilance for angiosarcoma in patients with a history of lymphedema surgery.
  • Further research is needed to understand the pathogenesis and improve treatment strategies for post-surgical angiosarcoma.
  • Early detection and novel therapeutic approaches are crucial for improving outcomes in patients with this rare malignancy.