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Updated: Mar 19, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Management of catheter-associated upper extremity deep venous thrombosis
Jeffrey D Crawford1, Timothy K Liem1, Gregory L Moneta1
1Division of Vascular Surgery, Department of Surgery, Oregon Health and Science University, Portland, Ore.
Insights
Central venous catheters increase the risk of upper extremity deep venous thrombosis (UEDVT). This review covers catheter-associated UEDVT, focusing on risk factors, diagnosis, prevention, and management strategies.
Area of Science:
- Vascular Medicine
- Thrombosis Research
- Medical Device Complications
Background:
- Central venous catheters (CVCs) and peripherally inserted central catheters (PICCs) are significant risk factors for upper extremity deep venous thrombosis (UEDVT).
- While literature on catheter-associated (CA) UEDVT has grown, robust evidence for clinical application in screening, diagnosis, prevention, and treatment remains limited.
Purpose of the Study:
- To review current evidence on catheter-associated upper extremity deep venous thrombosis (CA-UEDVT) applicable to clinical practice.
- To consolidate information on CA-UEDVT, including anatomy, risk factors, diagnostic methods, and management.
Main Methods:
- Literature review of current evidence on CA-UEDVT.
- Focus on clinically applicable findings related to risk, diagnosis, and management.
Main Results:
- Central venous catheters are identified as major risk factors for UEDVT.
- Duplex ultrasound is highlighted as the preferred diagnostic modality for CA-UEDVT.
- Preventive strategies and a management algorithm for CA-UEDVT are discussed.
Conclusions:
- Limited strong evidence exists for screening, diagnosis, prevention, and treatment of CA-UEDVT.
- A comprehensive review of CA-UEDVT, including risk factors and management, is presented to guide clinical practice.
Abstract:
Central venous catheters or peripherally inserted central catheters are major risk factors for upper extremity deep venous thrombosis (UEDVT). The body and quality of literature evaluating catheter-associated (CA) UEDVT have increased, yet strong evidence on screening, diagnosis, prevention, and optimal treatment is limited. We herein review the current evidence of CA UEDVT that can be applied clinically. Principally, we review the anatomy and definition of CA UEDVT, identification of risk factors, utility of duplex ultrasound as the preferred diagnostic modality, preventive strategies, and an algorithm for management of CA UEDVT.
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