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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
A hepatitis E outbreak by genotype 4 virus in Shandong province, China
Li Zhang1, Bingyu Yan1, Aiqiang Xu1
1Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, China; Academy of Preventive Medicine, Shandong University, Jinan, China.
Abstract:
Hepatitis E vaccine was available in China in 2012, but the priority population for immunization is not clear. In 2013, a hepatitis E outbreak occurred in a company of Shandong province, China where most employees moved from other provinces and dined at the company's cafeteria. A total of fourteen (19%, 14/73) case-patients were identified, and three of them had symptomatic infection with one death. The proportion of symptomatic infection was much higher among those aged ⩾50years than those aged <50years (2/2 vs. 1/12, P=0.03), and higher in males than females (3/8 vs. 0/6, P=0.21). Food in the company's cafeteria might be the possible source of the outbreak. The findings from this outbreak investigation indicate that individuals aged ⩾50years, particularly males, might be the population of top priority for hepatitis E vaccination in China.
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