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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
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Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Cancer Stem Cells.

Wendy A Woodward1, Richard P Hill2,3

  • 1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. wwoodward@mdanderson.org.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|June 20, 2016
PubMed
Summary
This summary is machine-generated.

Cancer stem cells in solid tumors are complex, arising from dedifferentiation or mutations. Therapies targeting these cells are advancing, showing clinical relevance and offering new patient care strategies.

Keywords:
Cancer stem cellsMicroenvironmentStem cell markersStem cell modelsStem cell resistance

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Area of Science:

  • Oncology
  • Stem Cell Biology

Background:

  • The cancer stem cell (CSC) model has evolved from early parallels between hematologic malignancies and solid tumors.
  • Putative CSCs can arise through dedifferentiation, context-induced changes, or accumulated genetic mutations.

Purpose of the Study:

  • To review the evolution of the CSC model in solid tumors.
  • To highlight the growing clinical relevance and therapeutic strategies targeting CSCs.
  • To identify outstanding research areas in the field.

Main Methods:

  • Literature review of the cancer stem cell model in solid tumors.
  • Analysis of the evolution of hypotheses regarding CSCs and recurrence.
  • Identification of clinical strategies targeting CSCs.

Main Results:

  • The CSC model has become more complex, moving beyond simple stem cell therapies for recurrence.
  • Evidence for the clinical relevance of CSCs in patient care has increased.
  • Numerous strategies to target CSCs in patients have been identified.

Conclusions:

  • The understanding of cancer stem cells in solid tumors has significantly advanced.
  • Targeting cancer stem cells holds promise for improving patient care and treatment outcomes.
  • Further research is needed to fully elucidate and exploit the clinical potential of targeting CSCs.