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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Transthoracic 3D Echocardiographic Left Heart Chamber Quantification Using an Automated Adaptive Analytics Algorithm.

Wendy Tsang1, Ivan S Salgo2, Diego Medvedofsky3

  • 1Division of Cardiology, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada; University of Chicago Medical Center, Chicago, Illinois.

JACC. Cardiovascular Imaging
|June 20, 2016
PubMed
Summary
This summary is machine-generated.

An automated algorithm for 3D transthoracic echocardiography (TTE) accurately quantifies left atrial (LA) and left ventricular (LV) volumes and ejection fraction (LVEF). This timesaving technique is comparable to manual measurements and cardiac magnetic resonance (CMR), facilitating clinical integration.

Keywords:
3-dimensional echocardiographyautomationcardiac chamber quantification

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Echocardiography

Background:

  • 3D transthoracic echocardiography (TTE) offers superior cardiac chamber quantification compared to 2D TTE.
  • Clinical adoption of 3D TTE is hindered by time-intensive workflows and the need for specialized expertise.
  • A novel automated software has been developed for volumetric quantification from 3D TTE datasets.

Purpose of the Study:

  • To evaluate the feasibility and accuracy of an automated algorithm for simultaneous quantification of 3D TTE-derived left atrial (LA) and left ventricular (LV) volumes and left ventricular ejection fraction (LVEF).
  • To compare automated measurements with conventional manual 3D TTE tracings and cardiac magnetic resonance (CMR) imaging.

Main Methods:

  • 159 patients were studied across two protocols.
  • Protocol 1: Automated software (HeartModel) measurements of LA and LV volumes and LVEF were compared to manual 3D TTE measurements from three readers.
  • Protocol 2: Automated measurements were compared against a CMR reference standard.

Main Results:

  • Strong correlations were observed between automated and manual 3D TTE measurements (r = 0.87–0.96).
  • Automated analysis showed strong agreement with CMR (r = 0.84–0.95).
  • Low test-retest variability and minimal overestimation of volumes/underestimation of LVEF compared to manual methods were noted.

Conclusions:

  • Automated simultaneous quantification of LA and LV volumes and LVEF using 3D TTE is feasible and accurate.
  • The automated method is comparable to manual measurements and CMR, requiring minimal training.
  • This reproducible and time-saving technique facilitates the clinical integration of 3D TTE for left-heart chamber assessment.