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Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Carbohydrate Metabolism01:36

Carbohydrate Metabolism

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Isolation of Human Islets from Partially Pancreatectomized Patients
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Co-Managing Patients with Type 1 Diabetes and Cancer.

Conor J Best1, Sonali Thosani2, Marjorie Ortiz2

  • 1MD Anderson Cancer Center, Endocrine Neoplasia and Hormonal Disorders, 1400 Pressler St. Unit 1461, Houston, TX, 77030-4009, USA. cjbest@mdanderson.org.

Current Diabetes Reports
|June 21, 2016
PubMed
Summary
This summary is machine-generated.

People with type 1 diabetes are living longer and increasingly face cancer. Effective cancer treatment requires careful management of blood sugar levels to prevent complications.

Keywords:
CancerChemotherapyGlucocorticoidsHyperalimentationTargeted cancer therapyType 1 diabetes

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Area of Science:

  • Oncology
  • Endocrinology
  • Diabetes Management

Background:

  • Improving life expectancy for type 1 diabetes (T1D) patients means more will face cancer.
  • Cancer treatments, including glucocorticoids and targeted therapies, significantly impact insulin needs and glycemic control.
  • Cancer patients often experience gastrointestinal issues and require nutritional support, further complicating diabetes management.

Purpose of the Study:

  • To highlight the challenges of managing type 1 diabetes in cancer patients.
  • To emphasize the critical role of glycemic control in cancer outcomes.
  • To advocate for collaborative care between oncologists and diabetologists.

Main Methods:

  • Review of existing literature on diabetes and cancer treatment.
  • Analysis of mechanisms by which cancer therapies affect glucose metabolism.
  • Discussion of nutritional support in cancer patients with diabetes.

Main Results:

  • Cancer treatments can cause significant fluctuations in insulin requirements.
  • Hyperglycemia and hypoglycemia pose risks to cancer patients with T1D.
  • Glycemic control appears to be a significant factor in cancer outcomes.

Conclusions:

  • Close collaboration between oncologists and diabetologists is essential for optimal cancer treatment in T1D patients.
  • Managing hyperglycemia and avoiding hypoglycemia are crucial for effective cancer therapy and patient well-being.
  • Further research is needed to fully understand the interplay between T1D, cancer, and treatment outcomes.