Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

4.0K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
4.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.0K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.8K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.9K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.9K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

Cell·2026
Same author

Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins.

European journal of immunology·2025
Same author

Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseases.

Nature communications·2025
Same author

Altered Thymopoiesis in Thymoma Is Associated with Defects in Negative Selection Machinery and Decreased Treg Abundance.

Cancer immunology research·2025
Same author

Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma.

Cancer immunology research·2025
Same author

Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer.

Cell reports. Medicine·2025

Related Experiment Video

Updated: Mar 19, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

8.7K

Dendritic cell maturation and cross-presentation: timing matters!

Andrés Alloatti1, Fiorella Kotsias1,2, Joao Gamelas Magalhaes1

  • 1Institut Curie, PSL Research University, INSERM U932, Paris Cedex 05, France.

Immunological Reviews
|June 21, 2016
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) excel at cross-presentation of antigens. Their unique phagocytic pathway control is key for effective CD8(+) T-cell responses and vaccination strategies.

Keywords:
cross-presentationdendritic celldendritic cells maturationphagocytosistoll-like receptor

More Related Videos

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.8K
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

21.4K

Related Experiment Videos

Last Updated: Mar 19, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

8.7K
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.8K
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

21.4K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are potent antigen-presenting cells.
  • DCs are particularly effective at cross-presentation of internalized antigens via MHC class I molecules.

Purpose of the Study:

  • To explore the unique mechanisms dendritic cells employ for antigen cross-presentation.
  • To understand how innate signaling regulates DC phagocytic functions for adaptive immunity.

Main Methods:

  • Investigated DC phagocytic and endocytic pathways.
  • Analyzed mechanisms controlling phagosome acidification, degradation, lysosomal fusion, ER protein recruitment, and antigen export.

Main Results:

  • Dendritic cells possess specialized pathways to limit phagosome acidification and proteolytic degradation.
  • DCs can delay phagosome-lysosome fusion and recruit ER proteins to phagosomes.
  • Phagocytosed antigens are exported to the cytosol by DCs for cross-presentation.

Conclusions:

  • DC's unique phagocytic pathway regulation is crucial for antigen processing and presentation.
  • Understanding these innate signaling pathways is vital for developing effective CD8(+) T-cell vaccination strategies.