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Published on: December 9, 2022
Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical
Thorsten Brenner1, Florian Uhle1, Thomas Fleming2
1a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Objectives:
The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings.
Methods:
Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers.
Results:
Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein. Moreover, sTREM-1 was identified to be an early predictor for survival in patients with septic shock.
Conclusion:
Due to its diagnostic as well as prognostic value in sepsis syndrome, implementation of sTREM-1 measurements in routine diagnostics should be taken into account.
