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Related Experiment Video

Updated: Mar 19, 2026

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

Published on: June 20, 2018

Methotrexate-Induced Nasal Septal Perforation.

Edidiong Ntuen Kaminska¹, Freda Sansaricq², Vesna Petronic-Rosic³

¹University of Chicago Pritzker School of Medicine, Section of Dermatology, Chicago, IL.

|June 21, 2016

Summary

This study explores methotrexate treatment for refractory Hailey-Hailey disease. The findings suggest methotrexate may offer an alternative therapeutic option for this chronic skin condition.

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Area of Science:

Dermatology
Immunology

Background:

Hailey-Hailey disease (HH) is a chronic, relapsing blistering skin disorder.
Treatment resistance is common in HH, necessitating exploration of alternative therapies.

Observation:

A 58-year-old woman with a 31-year history of refractory HH disease presented for new treatment options.
The patient exhibited active, eroded, and crusted plaques in intertriginous areas.

Findings:

The patient was treated with oral methotrexate (10-15 mg/week) and folic acid supplementation for 3 years.
Intermittent clarithromycin and prednisone were used for antibacterial and anti-inflammatory effects.

Implications:

Methotrexate may represent a viable alternative treatment for recalcitrant Hailey-Hailey disease.
Further research is warranted to establish the efficacy and safety of methotrexate in HH management.