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Effect Modification and Interaction Terms: It Takes Two to Tango
1Assistant Professor, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX.
Abstract:
In this Investigators' Corner I look more deeply into the previously discussed phenomenon of effect modification. I revisit an explanation and examples of the phenomenon and then examine how to account for it statistically. Specifically, I show, in detail, how to write a regression equation that includes interaction terms that account for the effect modification. Finally, I look at interpretation of regression coefficients both with and without the presence of effect modification, and the associated interaction terms.
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