Related Experiment Video

Updated: Mar 19, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Rexinoids for prevention and treatment of cancer: opportunities and challenges

Karen T Liby1, Michael B Sporn

  • 1Michigan State University, Department of Pharmacology & Toxicology, B430 Life Science Building, 1355 Bogue Street, East Lansing, MI 48824. liby.kare@msu.edu.

Current Topics in Medicinal Chemistry
|June 21, 2016
PubMed

Insights

Rexinoids selectively target nuclear receptors (RXRs) and show promise in cancer therapy. These compounds suppress cancer cell growth, reduce inflammation, and prevent cancer in animal models, offering synergistic therapeutic potential.

Area of Science:

  • Pharmacology
  • Oncology
  • Molecular Biology

Background:

  • Rexinoids are selective ligands for Retinoid X Receptors (RXRs), distinct from Retinoic Acid Receptors (RARs).
  • Emerging research highlights rexinoids' potential in cancer treatment and prevention.

Purpose of the Study:

  • To review the literature on four specific rexinoids: bexarotene, LG100268, LG101506, and NRX194204.
  • To summarize their effects on cancer cell proliferation, inflammatory cell activation, and carcinogenesis.

Main Methods:

  • Literature review of studies investigating rexinoid activity.
  • Analysis of preclinical data from animal models of human disease.

Main Results:

  • The reviewed rexinoids demonstrated efficacy in suppressing cancer cell proliferation.
  • These agents inhibited the activation of inflammatory cells within the tumor microenvironment.
  • Rexinoids showed potential in preventing carcinogenesis in relevant animal models.

Conclusions:

  • The rexinoids studied possess significant anti-cancer and anti-inflammatory properties.
  • They exhibit potent synergistic effects when combined with other pharmacological agents.
  • These findings suggest promising clinical applications for rexinoids in cancer therapy.

More Related Videos

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling05:03

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Published on: December 27, 2024

1.8K
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

12.2K

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

2.8K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.6K
Cancer Prevention02:59

Cancer Prevention

3.0K
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
1
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.1K