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Published on: May 21, 2019
The Uranyl Cation as a Visible-Light Photocatalyst for C(sp(3) )-H Fluorination
Julian G West1, T Aaron Bedell1, Erik J Sorensen2
1Department of Chemistry, Princeton University, Princeton, NJ, USA.
Abstract:
The fluorination of unactivated C(sp(3) )-H bonds remains a desirable and challenging transformation for pharmaceutical, agricultural, and materials scientists. Previous methods for this transformation have used bench-stable fluorine atom sources; however, many still rely on the use of UV-active photocatalysts for the requisite high-energy hydrogen atom abstraction event. Uranyl nitrate hexahydrate is described as a convenient, hydrogen atom abstraction catalyst that can mediate fluorinations of certain alkanes upon activation with visible light.
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