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Outcome of Liver Transplantation in Hepatocellular Carcinoma Patients at Siriraj Hospital.

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Correlation of Hematocrit and Tacrolimus Level in Liver Transplant Recipients.

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Immunosuppressive Medication Adherence in Liver Transplant Recipients.

R Promraj1, W Dumronggittigule2, Y Sirivatanauksorn2

  • 1Ambulatory Care Unit, Pharmacy Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

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|June 21, 2016
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Consistent assessment of immunosuppressive medication adherence is crucial for liver transplant recipients. The Siriraj-Support Medication Adherence in Organ Transplantation (S-SMAOT) program effectively improved patient adherence and outcomes.

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Area of Science:

  • Transplantation medicine
  • Clinical pharmacology
  • Patient adherence studies

Background:

  • Immunosuppressive medication is critical for liver transplant patient outcomes.
  • Nonadherence to immunosuppressive therapy negatively impacts graft and patient survival.
  • Assessing medication adherence is vital for successful liver transplantation.

Purpose of the Study:

  • To evaluate immunosuppressive medication adherence in liver transplant recipients.
  • To identify factors influencing medication adherence post-transplantation.
  • To assess the effectiveness of the S-SMAOT program in improving adherence.

Main Methods:

  • Cross-sectional study involving liver transplant recipients in the S-SMAOT program.
  • Immunosuppressive medication adherence assessed using the Immunosuppressive Therapy Adherence Scale (ITAS).
  • Analysis of correlations between ITAS scores, clinical profiles, duration post-transplant, and educational scores.

Main Results:

  • 82.6% of patients demonstrated excellent adherence (ITAS score 12).
  • ITAS scores significantly correlated with duration after transplantation (P < .001) and educational scores (P = .009).
  • The S-SMAOT program was associated with high medication adherence rates.

Conclusions:

  • Regular assessment of immunosuppressive medication adherence is essential for preventing noncompliance and improving liver transplant outcomes.
  • The S-SMAOT program demonstrated effectiveness in significantly enhancing medication adherence.
  • Improved adherence is linked to better graft and patient survival post-liver transplantation.