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Published on: September 7, 2017
The dynamic changes of DNA methylation in primordial germ cell differentiation
Lian Duan1, Yongmei Liu2, Jie Wang2
1Department of Cardiology, Guang' an men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, China.
Abstract:
The discovery of DNA methylation has provided a new perspective on how DNA may be dynamically regulated in the mammalian genome. DNA methylation is a dynamic process with a demethylation and de novo methylation from primordial germ cell to differentiation. DNA methylation and demethylation have been proposed to play important roles in somatic cell reprogramming. Some essential components were discussed, such as hydroxymethylation which has recently been confirmed as a modification of developmental importance.
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