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Anticoagulants in dermatology.

Keshavmurthy A Adya¹, Arun C Inamadar¹, Aparna Palit¹

¹Department of Dermatology, Venereology and Leprosy, Shri B. M. Patil Medical College, Hospital and Research Center, BLDE University, Vijayapur, Karnataka, India.

Indian Journal of Dermatology, Venereology and Leprology

|June 21, 2016

Summary

Anticoagulants are crucial for treating blood clots and various dermatologic conditions. While effective, they can cause adverse skin reactions, necessitating careful monitoring in patients.

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Area of Science:

Pharmacology
Dermatology
Hematology

Background:

Anticoagulants are essential for managing venous thromboembolism (VTE) across diverse medical and surgical contexts.
Their classification includes heparins, vitamin K antagonists, and direct inhibitors of thrombin and factor Xa, with ongoing advancements in oral and parenteral agents.

Purpose of the Study:

To review the therapeutic applications of anticoagulants in dermatology for both thrombotic and non-thrombotic skin conditions.
To highlight the dermatologic adverse effects associated with anticoagulant therapy.

Main Methods:

Literature review of anticoagulant mechanisms, classifications, and clinical uses in dermatology.
Analysis of adverse dermatologic manifestations linked to anticoagulant use.

Main Results:

Anticoagulants are vital for treating cutaneous thrombotic dermatoses like livedoid vasculitis and purpura fulminans.
They also show utility in non-thrombotic dermatoses including lichen planus and chronic urticaria.
Significant dermatologic side effects include warfarin-induced skin necrosis and heparin-induced thrombocytopenia.

Conclusions:

Anticoagulants play a dual role in dermatology, offering therapeutic benefits for thrombotic and non-thrombotic conditions.
Awareness of potential dermatologic adverse effects is critical for safe and effective patient management.