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Published on: January 3, 2013
Prognostic values of B7-H4 in non-small cell lung cancer
Wei Wang1,2, Chunhua Xu1,2, Yuchao Wang1,2
1a Endoscopic Center of Nanjing Chest Hospital , Nanjing , Jiangsu 210029 , China.
Objective:
The aim of this study was to explore the prognostic value of serum soluble B7-H4 (sB7-H4) levels in patients with non-small cell lung cancer (NSCLC).
Methods:
Serum specimens from 316 NSCLC patients and 240 healthy controls were collected. The concentrations of sB7-H4 were measured by ELISA.
Results:
The levels of sB7-H4 in NSCLC patients were significantly higher than that of the controls (P<0.01). Multivariate survival analysis indicated that sB7-H4 was an independent prognostic indicator of overall survival and progression-free survival (P<0.01).
Conclusions:
Measurement of serum sB7-H4 might be a useful prognostic biomarker for NSCLC.
