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Related Experiment Video

Updated: Mar 19, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Warfarin-induced calciphylaxis in patients with normal renal function.

L Huilaja1,2, M Turpeinen3,4, H Tokola5,6

  • 1Department of Dermatology, Oulu University Hospital, Oulu, Finland.

Journal of Clinical Pharmacy and Therapeutics
|June 21, 2016
PubMed
Summary

Warfarin-induced calciphylaxis, a rare skin necrosis, can occur in patients with normal kidney function. Sodium thiosulphate shows promise in treating this condition, highlighting the need for better clinical recognition.

Keywords:
adverse effectcalciphylaxischronic ulcersodium thiosulphatewarfarin

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Area of Science:

  • Dermatology
  • Nephrology
  • Vascular Medicine

Background:

  • Calciphylaxis is a rare, severe condition causing skin necrosis, often associated with kidney disease.
  • Recognition of calciphylaxis in non-uraemic patients is limited.

Observation:

  • This study details five cases of warfarin-induced calciphylaxis in patients with normal renal function.
  • Obesity and warfarin were identified as potential contributing factors.
  • Sodium thiosulphate was administered as a treatment in four of the cases.

Findings:

  • Warfarin-induced calciphylaxis is an under-recognized entity in patients without kidney disease.
  • Sodium thiosulphate demonstrated positive treatment outcomes in the observed cases.
  • The study emphasizes the importance of considering calciphylaxis in patients presenting with unexplained skin necrosis.

Implications:

  • Improved clinical awareness of calciphylaxis in non-uraemic patients is crucial.
  • Sodium thiosulphate represents a potential therapeutic option for warfarin-induced calciphylaxis.
  • Further research is warranted to elucidate the pathogenesis and optimize treatment strategies for calciphylaxis.