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Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes
Ghada Al-Kafaji1, Ghazi Al-Mahroos2, Haifa Abdulla Al-Muhtaresh1
1a College of Medicine and Medical Sciences , Arabian Gulf University , Manama , Kingdom of Bahrain.
Abstract:
Circulating microRNAs (miRNAs) have been shown as promising biomarkers for various diseases. We investigated the predictive potential of circulating endothelium-enriched miR-126 in type 2 diabetes patients (T2D) without chronic complications and T2D patients with coronary artery diseases (CAD). The expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls. MiR-126 strongly associated with T2D and CAD, negatively correlated with LDL in CAD patients and differentiated between T2D patients, T2D patients with CAD and healthy subjects. Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.
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