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Related Experiment Videos

Medullary expiratory activity during opossum development.

J P Farber1

  • 1Department of Physiology and Biophysics, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 1, 1989
PubMed
Summary

Medullary expiratory neurons in young opossums show increased activity and faster response during positive pressure breathing (PPB). Their discharge is more sensitive to unloading compared to adult opossums, indicating developmental changes in respiratory control.

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Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • Medullary expiratory neurons play a crucial role in respiratory control.
  • Understanding the development of these neurons is essential for comprehending respiratory regulation.

Purpose of the Study:

  • To investigate the properties of medullary expiratory neurons in developing opossums.
  • To compare the activity and response to breathing changes in suckling versus adult opossums.

Main Methods:

  • Recorded medullary expiratory neuronal action potentials in Inactin-anesthetized suckling opossums (30-90 days old).
  • Utilized positive pressure breathing (PPB) to assess neuronal discharge during controlled ventilation.
  • Examined neuronal responses to PPB removal and reinstatement, and spinal cord projections.

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Main Results:

  • Expiratory cell discharge rate increased with age during PPB.
  • The delay between inspiration cessation and expiratory discharge decreased with age.
  • Suckling opossum expiratory cells were more likely to become silent during unloaded breathing compared to adult opossums.

Conclusions:

  • Medullary expiratory neurons undergo significant developmental changes in suckling opossums.
  • These developing neurons exhibit heightened sensitivity to changes in respiratory loading.
  • Findings suggest a maturational process in the neural control of breathing from infancy to weaning.