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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Chronic Pancreatitis I: Introduction01:24

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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Updated: Mar 19, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
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[Cutaneous panniculitis].

C Velter1, D Lipsker1

  • 1Clinique dermatologique, hôpitaux universitaires de Strasbourg, faculté de médecine, université de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.

La Revue De Medecine Interne
|June 21, 2016
PubMed
Summary
This summary is machine-generated.

Panniculitis diagnosis relies on skin biopsy, differentiating septal or lobular inflammation and vasculitis. Histopathology guides challenging treatment, sometimes requiring repeat biopsies for accurate diagnosis.

Keywords:
Erythema nodosumLupus erythematosusLupus érythémateuxNodular vasculitisPanniculitePanniculitisPolyarteritis nodosaPériartérite noueuseVasculite nodulaireÉrythème noueux

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Panniculitis involves inflammation of subcutaneous fat.
  • Accurate diagnosis is crucial for effective treatment.
  • Skin biopsy is a key diagnostic tool for most panniculitis types.

Purpose of the Study:

  • To outline the diagnostic approach to panniculitis.
  • To emphasize the role of histopathology in differentiating subtypes.
  • To highlight the importance of clinical-histological correlation.

Main Methods:

  • Histopathological examination of deep cutaneous biopsies.
  • Classification based on septal or lobular patterns and presence of vasculitis.
  • Microbiological analysis and T-cell clonal expansion testing when indicated.

Main Results:

  • Diagnosis hinges on differentiating septal vs. lobular panniculitis and presence/absence of vasculitis.
  • Specific subtypes like erythema nodosum may not require biopsy.
  • Distinguishing between conditions like lupus panniculitis and subcutaneous panniculitis-like T-cell lymphoma requires careful evaluation.

Conclusions:

  • Skin biopsy is essential for diagnosing most panniculitis cases.
  • Treatment strategies are guided by histopathological findings.
  • Ongoing patient follow-up and potential repeat biopsies are important for management.