Related Experiment Video
Updated: Mar 19, 2026
12:33
High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
Published on: November 15, 2013
48.7K
[Not Available]
P P Urban1, S Wicht1, C Fitzek2
1Klinik und Poliklinik für Neurologie der Universität Mainz, Germany.
Klinische Neuroradiologie
|June 21, 2016
Summary
Sudden dysarthria in patients is often caused by extracerebellar infarctions affecting corticobulbar pathways for volitional movement control. Cerebellar infarctions impair articulatory coordination, with extracerebellar lesions more common in the left hemisphere.
Area of Science:
- Neurology
- Neuroimaging
- Stroke Research
Context:
- Sudden onset dysarthria can indicate a stroke.
- Understanding the precise location of brain infarction is crucial for diagnosis and treatment.
- Magnetic Resonance Imaging (MRI) is a key tool for identifying stroke lesions.
Purpose:
- To investigate the lesion topography of sudden onset dysarthria.
- To correlate infarction locations with specific deficits in speech production.
- To differentiate the effects of extracerebellar versus cerebellar infarctions on dysarthria.
Summary:
- A prospective study examined 106 patients with sudden dysarthria from single, non-space-occupying infarctions confirmed by MRI.
- Extracerebellar infarctions were prevalent (81.1%), frequently involving the pons and centrum semiovale, predominantly in the left hemisphere.
- Cerebellar infarctions occurred in the rostral paravermal region; combined lesions were seen in 10.4%.
- Extracerebellar lesions impact volitional movement via corticobulbar pathways, while cerebellar lesions affect articulatory coordination.
Impact:
- Provides detailed topographical data on stroke-induced dysarthria.
- Enhances understanding of the neural basis of speech production and its disruption by stroke.
- Aids in the clinical localization of stroke based on dysarthria presentation.
