Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

56
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
56
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

120
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
120
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.4K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.4K
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

1.9K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.9K
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

1.0K
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
1.0K
Antidotes01:17

Antidotes

1.3K
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of an Esophageal‑Protective Lithium Coin‑Cell Battery Within Current Management Paradigms.

OTO open·2026
Same author

Comparison of two-bag and three-bag acetylcysteine regimens in the treatment of paracetamol poisoning: a systematic review and meta-analysis.

Clinical toxicology (Philadelphia, Pa.)·2025
Same author

The Impact of Legalizing Recreational Cannabis on the Children of a Neighboring State.

Pediatric emergency care·2024
Same author

2020 webPOISONCONTROL data summary.

The American journal of emergency medicine·2022
Same author

Human toxicity from COVID-19 rapid home test kits.

The American journal of emergency medicine·2022
Same author

The current state of delta-8 THC.

The American journal of emergency medicine·2021

Related Experiment Video

Updated: Mar 19, 2026

Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays
08:06

Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays

Published on: November 10, 2016

8.0K

webPOISONCONTROL: can poison control be automated?

Toby Litovitz1, Blaine E Benson2, Susan Smolinske3

  • 1National Capital Poison Center, Washington, DC; Department of Emergency Medicine, Georgetown University School of Medicine, Washington, DC; The George Washington University School of Medicine, Washington, DC.

The American Journal of Emergency Medicine
|June 21, 2016
PubMed
Summary

The webPOISONCONTROL app offers a safe and user-friendly way to triage poison ingestions online, improving access to poison control guidance. This automated tool provides quick, accurate recommendations for home care or further medical attention.

More Related Videos

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

12.0K
A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
14:10

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Published on: November 14, 2014

9.0K

Related Experiment Videos

Last Updated: Mar 19, 2026

Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays
08:06

Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays

Published on: November 10, 2016

8.0K
Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

12.0K
A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
14:10

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Published on: November 14, 2014

9.0K

Area of Science:

  • Toxicology
  • Digital Health
  • Public Health

Background:

  • Poison control services are traditionally accessed via telephone.
  • A free webPOISONCONTROL app offers an alternative for online triage of poison ingestions.
  • This study evaluates the feasibility, safety, and user acceptance of this automated online triage system for non-emergency cases.

Purpose of the Study:

  • To assess the feasibility, safety, and user acceptance of the webPOISONCONTROL app for automated triage of poison ingestions.
  • To determine if online triage can expand access to reliable poison control information.
  • To evaluate the effectiveness of automated triage for asymptomatic, non-suicidal ingestions.

Main Methods:

  • Users input substance, amount, age, and weight into the app.
  • The tool provides triage recommendations: stay home, go to ED, or call poison control.
  • Safety was assessed via outcomes of home-triaged cases; user acceptance measured by completion time and user perception.

Main Results:

  • 9,256 cases were analyzed; 73.3% triaged to home, 2.1% to ED, 24.5% to call poison control.
  • Children under 6 comprised 75.2% of cases.
  • No major or fatal outcomes reported; 91% found the tool quick and easy to use.

Conclusions:

  • webPOISONCONTROL successfully augments traditional poison control services.
  • The app provides automated, accurate, and accessible triage and first aid guidance.
  • The tool is demonstrated to be safe, quick, and user-friendly for poison ingestion management.