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Published on: July 8, 2015
Bidirectional prefrontal-hippocampal interactions support context-guided memory
Ryan Place1, Anja Farovik1, Marco Brockmann1
1Center for Memory and Brain, Boston University, Boston, Massachusetts, USA.
Abstract:
We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.
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