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Updated: Mar 19, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

The mouse cortico-striatal projectome.

Houri Hintiryan¹, Nicholas N Foster¹, Ian Bowman¹

¹USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

Nature Neuroscience

|June 21, 2016

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This summary is machine-generated.

This study maps mouse brain connections from the cortex to the striatum, revealing 29 functional domains. This provides a structural map for understanding striatal diversity and brain disorders.

Area of Science:

Neuroscience
Computational Neuroanatomy
Systems Neuroscience

Background:

Cortical areas form distinct subnetworks, but their subcortical interactions remain unclear.
Understanding cortico-striatal networks is crucial for deciphering basal ganglia function and dysfunction.

Purpose of the Study:

To create a comprehensive mesoscale mouse cortico-striatal projectome mapping projections from the entire cortex to the dorsal striatum (caudoputamen, CP).
To identify functional domains within the striatum and characterize cortico-striatal networks using computational neuroanatomical tools.
To demonstrate the utility of the developed workflow for studying circuitry-specific connectopathies in mouse models.

Main Methods:

Development of an open-access, mesoscale mouse cortico-striatal projectome.

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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

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Application of novel computational neuroanatomical tools to analyze projection data.

Analysis of cortico-striatal connections in wild-type and mouse models of disconnection syndromes.

Main Results:

Identification of 29 distinct functional striatal domains based on cortical projections.
Characterization of diverse cortico-striatal networks and their reconfiguration along the rostral-caudal axis of the CP.
Demonstration of the workflow's capability in characterizing circuitry-specific connectopathies.

Conclusions:

The study provides a detailed structural map of cortico-striatal connectivity.
This projectome serves as a foundation for investigating the functional diversity of the dorsal striatum.
The findings are essential for understanding disruptions in cortico-basal ganglia networks relevant to various neurological and psychiatric disorders.