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Evaluation and study of antimicrobial activity of nanoliposomal meropenem against Pseudomonas aeruginosa isolates

Momeni-Javid Zahra1, Hamishekar Hamed2, Rahmati-Yamchi Mohammad1,2

  • 1a Department of Medical Biotechnology, Faculty of Advanced Medical Science , Tabriz University of Medical Science , Tabriz , Iran.

Artificial Cells, Nanomedicine, and Biotechnology
|June 21, 2016
PubMed
Abstract

Insights

Liposomal meropenem demonstrates superior antimicrobial efficacy against Pseudomonas aeruginosa, significantly reducing minimum inhibitory and bactericidal concentrations. This novel formulation also effectively eradicates biofilms and inhibits bacterial motility.

Area of Science:

  • Microbiology
  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Pseudomonas aeruginosa is a significant opportunistic pathogen.
  • Antibiotic resistance in P. aeruginosa poses a major clinical challenge.
  • Novel drug delivery systems are needed to enhance antimicrobial efficacy.

Purpose of the Study:

  • To evaluate the antimicrobial efficacy of liposomal meropenem against P. aeruginosa.
  • To compare liposomal meropenem with free meropenem.
  • To assess the impact on biofilm eradication and bacterial motility.

Main Methods:

  • Determined Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).
  • Assessed Minimum Biofilm Eradication Concentration (MBEC).
  • Evaluated inhibition of P. aeruginosa motility.

Main Results:

  • Liposomal meropenem showed significantly lower MICs and MBCs compared to free meropenem (6.25 μg/ml vs 100 μg/ml).
  • Liposomal meropenem completely eradicated P. aeruginosa biofilms at concentrations as low as ≥1.5 μg/ml.
  • Lower concentrations of liposomal meropenem inhibited bacterial motility more effectively than the free form.

Conclusions:

  • Liposomal meropenem is more effective than meropenem alone against antibiotic-resistant P. aeruginosa.
  • Liposomal formulation enhances meropenem's activity against P. aeruginosa.
  • This formulation holds promise for treating P. aeruginosa infections.
Keywords:
Antibiotic resistanceP. aeruginosaliposomal meropenem

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