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Progress in the treatment and outcome of pediatric inflammatory bowel disease patients
Kaija-Leena Kolho1, Antti Ainamo2,3
1a Children´s Hospital , Helsinki University Central Hospital, University of Helsinki , Helsinki , Finland.
Insights
Pediatric inflammatory bowel disease (IBD) treatment has advanced with active therapies like immunosuppressants and biologics. Early disease control improves child development and quality of life, reducing the need for surgery.
Area of Science:
- Pediatric gastroenterology
- Inflammatory Bowel Disease (IBD) management
Background:
- Increasing incidence of pediatric inflammatory bowel disease (IBD) in Western countries.
- IBD encompasses Crohn's disease, ulcerative colitis, and unclassified colitis in children.
Purpose of the Study:
- To review advancements in pediatric IBD treatment, focusing on therapeutic quality and cost-effectiveness.
- To analyze the shift towards more active treatment strategies in pediatric IBD.
Main Methods:
- Literature search of Medline-PubMed and Cochrane Library up to February 2016.
- Review of therapeutic quality, cost, and treatment approaches for pediatric IBD.
Main Results:
- Pediatric IBD therapy has become more aggressive, mirroring adult IBD management trends.
- Increased use of immunosuppressants and biologics effectively controls extensive and aggressive pediatric IBD.
- Early and full disease control preserves normal growth, development, and quality of life, while reducing psychosocial burden.
Conclusions:
- Future research should focus on tailoring treatments to individual patient phenotypes and disease courses.
- Reducing healthcare costs by minimizing surgery and adopting proactive treatment strategies is crucial for pediatric IBD management.
Introduction:
The number of pediatric patients with inflammatory bowel disease (IBD), namely Crohn´s disease, ulcerative colitis and unclassified colitis, has rapidly increased in Western countries. Areas covered: This review discusses how the treatment of pediatric IBD patients has improved,with attention given to therapeutic quality and cost. The literature search covers Medline-PubMed and the Cochrane Library, with February 2016 as the last search dates. Similarly to what has been the trend in the management of adult IBD, pediatric IBD therapy has become more active than before. High use of immunosuppressants and the availability of biological therapeutic agents has helped to control the extensive and aggressive course of pediatric IBD. Full disease control at an early phase has advantages such as preserving normal child growth and development, maintaining overall good health and quality of life, as well as decreasing the psychosocial burden of the disease. Expert commentary: A key research direction is to tailor treatment modalities according to anticipated individual phenotype and disease course. Another is to reduce healthcare costs by decreasing the so-far high rate of surgery of pediatric IBD patients, and, instead, to develop a more active approach to treatment than before.
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