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A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis
Kristin L Griffiths1, Daniel O Villarreal2, David B Weiner2
1a Department of Molecular Microbiology , Washington University in St. Louis , St. Louis , MO , USA.
Human Vaccines & Immunotherapeutics
|June 21, 2016
Abstract:
Mycobacterium tuberculosis infects one third of the world's population. Due to variable efficacy of the Bacille Calmette Guerin (BCG) vaccine, development of novel TB vaccines remains a priority. Here, we demonstrate the protective efficacy of a novel multivalent DNA vaccine, which contains 15 synthetic antigens targeting the Mtb ESX secretion system.
