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Association between NOS3 genetic variants and coronary artery disease in the Han population

G L Zhao1, Q J Li2, H Y Lu3

  • 1Department of Internal and Emergency Medicine, Jining No. 1 People's Hospital, Jining, Shandong, China.

Genetics and Molecular Research : GMR
|June 21, 2016
PubMed

Insights

Genetic variations in the endothelial nitric oxide synthase (NOS3) gene are linked to coronary artery disease (CAD) risk in the Han Chinese population. Specific NOS3 polymorphisms may influence CAD development and progression.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Endothelial nitric oxide synthase (NOS3) is crucial in atherosclerotic disease and coronary artery disease (CAD).
  • Evidence suggests NOS3 gene polymorphisms influence CAD progression, but findings are controversial.
  • Investigating NOS3 genetic variants in the Han Chinese population is essential for understanding CAD pathogenesis.

Purpose of the Study:

  • To determine the association between NOS3 genetic variants and CAD in the Han Chinese population.
  • To analyze eight single nucleotide polymorphisms (SNPs) in the NOS3 gene for their correlation with CAD.

Main Methods:

  • Genotyping of eight NOS3 SNPs (rs1799983, rs2070744, etc.) using the MassARRAY system.
  • Comparison of allelic and genotypic frequencies between CAD patients and healthy controls.
  • Linkage disequilibrium analysis and haplotype analysis were performed.

Main Results:

  • Significant differences in allelic and genotypic frequencies for rs1799983 and rs2070744 polymorphisms were observed between CAD patients and controls.
  • The rs1799983 T allele and rs2070744 G allele showed significantly higher frequencies in CAD patients.
  • Strong linkage disequilibrium was detected, with specific haplotypes (T-T-C in block 1) being more prevalent in controls.

Conclusions:

  • NOS3 gene polymorphisms play a role in the susceptibility to CAD in the Han Chinese population.
  • Specific NOS3 variants may serve as potential biomarkers for CAD risk.
  • Further research into NOS3 polymorphisms can elucidate CAD pathogenesis.

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