[Effect of Sinusitis Mixture on Mucosa Cells after Functional Endoscopic Sinus Surgery]

Area of Science:

• Otolaryngology
• Rhinology
• Surgical Innovation

Background:

• Chronic sinusitis and nasal polyps significantly impact quality of life.
• Functional endoscopic sinus surgery (FESS) is a common treatment, but optimizing post-operative recovery is crucial.
• Novel therapeutic adjuncts are needed to enhance FESS outcomes.

Purpose of the Study:

• To evaluate the efficacy of a sinusitis mixture (SM) as a post-operative nasal douching agent in FESS.
• To determine if SM improves clinical outcomes and accelerates mucosal healing compared to standard care.
• To assess the impact of SM on key histological parameters of sinonasal mucosa.

Main Methods:

• A randomized controlled trial involving 50 chronic sinusitis patients undergoing FESS.
• Patients were assigned to nasal douching with either SM or Compound Sodium Chloride Injection.
• Nasal mucosal tissues were collected at baseline and at 4, 12, and 24 weeks post-surgery for histological analysis.

Main Results:

• Significant differences were observed between the SM and control groups in cavity cleaning time and mucosal epithelization time (P < 0.05).
• SM group showed improved numbers and ratios of ciliated and goblet cells in the upper epithelia compared to the control group (P < 0.05).
• Histological analysis indicated enhanced mucosal recovery and reduced inflammation in the SM group.

Conclusions:

• Sinusitis mixture (SM) effectively promotes and accelerates the cleaning and mucosal epithelization process following FESS.
• SM significantly aids in the recovery of mucosal ciliary structure and function in the ostium-meatus nasicomplex.
• SM represents a promising adjunctive therapy for improving post-operative outcomes in patients with chronic sinusitis and nasal polyps.