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Patient characteristics and risk factors of participants and non-participants in the NOR-COR study

John Munkhaugen1, Elise Sverre1, Kari Peersen2

  • 1a Department of Medicine , Drammen Hospital , Drammen , Norway.

Scandinavian Cardiovascular Journal : SCJ
|June 22, 2016
PubMed

Insights

Non-participants in coronary heart disease (CHD) studies often have more risk factors like depression and diabetes. This suggests current prevention studies may overestimate risk factor control in CHD patients.

Area of Science:

  • Cardiology
  • Public Health
  • Clinical Research

Background:

  • Coronary heart disease (CHD) patient populations in clinical studies may not fully represent the general CHD patient demographic.
  • Understanding differences between study participants and non-participants is crucial for accurate clinical research and effective public health strategies.

Purpose of the Study:

  • To compare patient characteristics and coronary risk factors between participants and non-participants in a survey of CHD patients.
  • To identify factors associated with non-participation in CHD clinical studies.

Main Methods:

  • A cross-sectional study analyzed data from hospital medical records of patients hospitalized for acute myocardial infarction and/or revascularization.
  • Compared characteristics and risk factors between study participants (n=1127) and non-participants (n=229) who declined consent.

Main Results:

  • Non-participants exhibited higher prevalence of women (28% vs. 21%), ethnic minorities (6% vs. 3%), living alone (26% vs. 19%), depression (19% vs. 6%), anxiety (9% vs. 3%), hypertension (54% vs. 43%), and diabetes (24% vs. 17%).
  • Significantly higher multi-adjusted odds ratios for non-participation were observed for Charlson comorbidity index (3.4) and depression (14.5).

Conclusions:

  • Non-participants in CHD studies present with a greater burden of coronary risk factors, potentially leading to an overestimation of risk factor control in existing prevention studies.
  • Patients with somatic comorbidity and depression are at higher risk of non-participation.
  • Developing new strategies to address non-adherence is essential for improving secondary prevention in CHD.
Abstract

Keywords:
Coronary heart diseasecoronary risk factorsnon-participationpatient characteristics

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