Related Experiment Video
Updated: Aug 10, 2026

Analyzing Murine Schwann Cell Development Along Growing Axons
Published on: November 21, 2012
Interaction of soluble and substratum-bound factors influences neurite elongation
Abstract:
Neurite elongation was investigated in explanted chick dorsal root ganglia (DRG) using either serum-supplemented or defined N1 medium and different culture substrata. The results indicate that there is no substantial difference in neurite elongation on the three substrata when ganglia are grown in N1 medium. In contrast, neurite length depends on the substratum in serum-supplemented medium and in general exceeds that obtained in N1 medium. Optimal neurite growth was observed in N1 medium when culture dishes have been precoated with serum. Our data suggest that while soluble serum molecules inhibit neurite growth adsorbed serum constituents clearly stimulate neurite elongation.
Related Concept Videos
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Regulation of Nuclear Protein Sorting
Excitatory and Inhibitory Effects of Neurotransmitters
Mechanism of Filopodia Formation
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Intracellular Signaling Affects Focal Adhesions
Some...

