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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid

Yoshihiko Noguchi1,2, Tomoyasu Hirose1,2, Aki Ishiyama1,2

  • 1Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Journal of Natural Medicines
|June 22, 2016
PubMed

Keywords:
5-Nor stemmadenine alkaloidAntimalarial agentChirality transfer intramolecular Michael reactionDiastereoselective 1,2-addition using indole nucleophileIminophosphorane mediated cascade reactionPseudo-aminal type structure

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