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Updated: Mar 19, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
[A 44 year old patient presenting with Ewing's sarcoma of the big toe]
W Weschenfelder1, R Lindner2, C Spiegel2
1Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Jena, Erlanger Allee 101, 07747, Jena, Deutschland. wolfram.weschenfelder@med.uni-jena.de.
Abstract:
We present the case of a patient with osseous Ewing's sarcoma of the big toe occurring during the healing process after a fracture of the little toe, which significantly delayed diagnosis, despite striking findings on imaging. We subsequently performed further diagnostics, neoadjuvant chemotherapy, tumor resection in the form of a resection of the first ray, and adjuvant chemotherapy. This case shows that the occurrence of a secondary disease should always be considered in untypical courses of healing.
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