Alzheimer's disease prevention: A way forward
F Bermejo-Pareja1, S Llamas-Velasco2, A Villarejo-Galende3
1Imas12 (Instituto de Investigación Hospital Universitario 12 de Octubre), Madrid, España; Cátedra Extraordinaria de Alzheimer y enfermedades Neurodegenerativas, Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, España; CIBERNED, Instituto de Investigación Carlos III, Madrid, España.
Primary prevention strategies, including education and lifestyle changes, can significantly reduce Alzheimer's disease (AD) incidence and delay its onset. Half of all Alzheimer's disease cases are preventable, offering a more optimistic outlook.
Area of Science:
- Neuroscience
- Gerontology
- Public Health
Background:
- Alzheimer's disease (AD) poses a growing challenge due to population aging.
- Past therapeutic approaches have faced limitations, possibly because AD develops over decades before clinical manifestation.
Purpose of the Study:
- To present an updated perspective on Alzheimer's disease.
- To highlight the potential of primary prevention in managing AD incidence and onset.
Main Methods:
- Review of recent studies on Alzheimer's disease prevention.
- Analysis of factors contributing to AD development and manifestation.
Main Results:
- Primary prevention strategies can effectively reduce AD incidence.
- Key interventions include education, managing cardiovascular risk factors, promoting healthy lifestyles, and specific drug treatments.
- Approximately 50% of AD cases may be preventable.
Conclusions:
- A more optimistic view of Alzheimer's disease management is proposed.
- Primary prevention offers a viable strategy to substantially decrease the future burden of Alzheimer's disease.
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