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Related Experiment Video

Updated: Mar 19, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Correlation Between Bispectral Index and Electrocorticographic Features During Epilepsy Surgery.

Martha Itzhel G Ramírez¹, Laura Regina Rodríguez-Arias¹, Areli O Santiago¹

¹1 Neuroanesthesiology Department. National Institute of Neurology, Mexico City, Mexico.

Clinical EEG and Neuroscience

|June 22, 2016

Summary

The bispectral index (BIS) and intraoperative electrocorticography (iECoG) show a nonlinear correlation during epilepsy surgery. Burst suppression patterns were absent with BIS scores above 60, indicating BIS is a variable measure.

Keywords:

bispectral index electrocorticography general anesthesia propofol temporal epilepsy surgery

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Last Updated: Mar 19, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

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Published on: December 6, 2016

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Published on: October 2, 2014

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Published on: April 15, 2015

Area of Science:

Neuroscience
Anesthesiology
Epileptology

Background:

Intraoperative electrocorticography (iECoG) guides epilepsy surgery.
Bispectral index (BIS) monitors anesthesia depth, including in epilepsy surgery.
Correlation between BIS and iECoG during epilepsy surgery is not well understood.

Purpose of the Study:

To evaluate the correlation between BIS values and iECoG parameters.
To optimize iECoG recording quality and duration in epilepsy surgery.

Main Methods:

Prospective study of 28 epilepsy surgery patients (Sept 2008-Oct 2013).
Anesthesia with propofol and fentanyl.
Correlated BIS values with iECoG parameters: burst suppression (BS), suppression time, background frequency, and Mathern et al. iECoG score.

Main Results:

Nonlinear polynomial cubic relationship observed between BIS and iECoG parameters.
BIS 40-60: iECoG BS <5s, background frequency 10-17 Hz, iECoG score 2.
No iECoG burst suppression observed with BIS > 60.

Conclusions:

BIS and iECoG parameters exhibit a nonlinear correlation during propofol-fentanyl anesthesia in epilepsy surgery.
BIS > 60 reliably indicates the absence of burst suppression patterns.
BIS is a nonlinear, multidimensional measure with high variability concerning iECoG parameters.