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Predictors of long-term drug survival for infliximab in psoriasis
Q Magis1, D Jullien2, C Gaudy-Marqueste1
1Department of Dermatology, Hôpital Timone, Assistance Publique des Hôpitaux de Marseille, UMR 911, INSERM CRO2, "Centre de recherche en oncologie biologique et onco phamacologie", Aix-Marseille University, Marseille, France.
Background:
Limited information is available regarding factors associated with long-term drug survival of infliximab for psoriasis in real life.
Objectives:
The main aim pf this study was to identify predictors of long-term (>12 months) drug survival among patients treated with infliximab for psoriasis in a real-world clinical setting.
Methods:
Retrospectively collected data, relating to disease, patient characteristics and treatment procedures, in a multicentre observational cohort of patients with moderate-to-severe plaque psoriasis treated with infliximab at eight university hospitals, 120 of whom maintained a response to infliximab for more than 12 months, were compared with prospectively collected data in the same centres from 54 patients who experienced secondary loss of response within a 12-month period.
Results:
Mean duration of drug survival of infliximab in patients with long-term drug survival was 41.12 months ± 20.64 SD vs. 8.5 months ± 2.43 SD in patients with a secondary loss of response. Multivariate analysis identified greater disease severity at treatment onset (PASI score >12) (OR = 5.18, 95% CI: 1.60-16.77, P = 0.006), high levels of initial psoriasis clearance (PASI-90 reduction or equivalent) (OR = 18.50, 95% CI: 4.56-74.45, P = 0.0001) and combination with methotrexate (OR = 13.15, 95% CI: 1.46-118.79, P = 0.022) as independent predictors of long-term drug survival and sustained efficacy of infliximab.
Conclusion:
Positive predictors for long-term drug survival of infliximab in real life were identified. Their impact on treatment management should be addressed in further prospective trials.
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