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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Mar 19, 2026

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation

Published on: April 27, 2021

How to interpret mast cell tests.

Thomas Waterfield¹, Emma Dyer², Kathryn Wilson³

¹Paediatric Emergency Department, Royal Belfast Hospital for Sick Children, Belfast, UK.

Archives of Disease in Childhood. Education and Practice Edition

|June 22, 2016

Summary

This summary is machine-generated.

Serum mast cell tryptase is a measurable enzyme from mast cells. This article reviews its physiology, measurement, and diagnostic use in anaphylaxis, mastocytosis, and leukemia.

Keywords:

Allergy General Paediatrics anaphylaxis mastocytosis tryptase

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Last Updated: Mar 19, 2026

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Published on: May 31, 2021

Area of Science:

Biochemistry
Immunology
Hematology

Background:

Mast cells are key immune cells.
Mast cell tryptase (tryptase) is an enzyme produced by mast cells.
Tryptase is easily measurable and linked to mast cell activation.

Purpose of the Study:

To review the physiology of mast cells and their relation to IgE-mediated anaphylaxis and mastocytosis.
To describe the technical aspects and normal ranges for tryptase testing.
To explore the diagnostic utility of serum tryptase levels.

Main Methods:

Literature review of mast cell physiology.
Discussion of tryptase measurement techniques.
Analysis of diagnostic performance data for serum tryptase.

Main Results:

Tryptase is a specific marker for mast cell activation.
Serum tryptase measurements have diagnostic value in anaphylaxis, mastocytosis, and certain leukemias.
Understanding tryptase levels aids in risk assessment and disease monitoring.

Conclusions:

Serum mast cell tryptase is a valuable diagnostic and monitoring tool.
The article provides a comprehensive overview of tryptase's role in clinical practice.
Further research can refine the application of tryptase testing.