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The evolution of methods for establishing evolutionary timescales.

Philip C J Donoghue1, Ziheng Yang2

  • 1School of Earth Sciences, University of Bristol, Life Sciences Building, Tyndall Avenue, Bristol BS8 1TQ, UK phil.donoghue@bristol.ac.uk.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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Fossils provide essential absolute time data for molecular clock dating, despite the fossil record

Keywords:
Bayesian inferencedivergence timesfossilsmolecular clock datingnode-calibrationstip-calibrations

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Area of Science:

  • Paleontology and Evolutionary Biology
  • Molecular Phylogenetics

Background:

  • The fossil record is inherently incomplete, potentially distorting views of species divergence and extinction.
  • Molecular clock methods can estimate divergence times but rely on fossil data for absolute calibration.

Purpose of the Study:

  • To review methods for integrating fossil evidence into molecular clock dating analyses.
  • To discuss the utility and challenges of using fossil data for phylogeny estimation and ancestor identification.

Main Methods:

  • Review of node-calibration techniques, constraining divergence times with fossil probability densities.
  • Review of tip-calibration techniques, assigning dates to fossil species at the tree tips based on rock strata.
  • Discussion of potential biases and limitations associated with both calibration methods.

Main Results:

  • Fossils are indispensable for calibrating molecular clock analyses, providing absolute geological time constraints.
  • Node-calibrations can be arbitrary; tip-calibrations may be overly sensitive to priors and morphological evolution issues.
  • Both methods have limitations that require careful consideration when interpreting divergence times.

Conclusions:

  • Integrating fossil data into molecular clock analyses is crucial but requires careful methodological choices.
  • Understanding the limitations of fossil data and calibration methods is key to accurate phylogenetic inference.
  • Fossil evidence remains vital for understanding evolutionary history and identifying ancestral lineages.