Related Experiment Video

Updated: Mar 19, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.7K

Depression in patients with hypertrophic cardiomyopathy: is there any relation with the risk factors for sudden

Artemis Igoumenou1, Giorgos Alevizopoulos2, Aris Anastasakis3

  • 1Oxford Health NHS Foundation Trust, Oxford, UK.

Heart Asia
|June 22, 2016
PubMed

Insights

Patients with hypertrophic cardiomyopathy (HCM) experience more depression than the general population. However, depressive symptoms are not linked to sudden death risk factors in HCM patients.

Area of Science:

  • Cardiology
  • Psychiatry
  • Clinical Research

Background:

  • Hypertrophic cardiomyopathy (HCM) is a significant cause of sudden cardiac death.
  • The psychological impact of chronic cardiac conditions, including depression, requires further investigation.
  • Understanding the relationship between mental health and cardiac risk factors is crucial for comprehensive patient care.

Purpose of the Study:

  • To determine if depressive symptoms correlate with risk factors for sudden death in patients diagnosed with hypertrophic cardiomyopathy (HCM).
  • To compare depression levels in HCM patients with the general population.
  • To explore the relationship between disease duration and depressive symptoms in HCM.

Main Methods:

  • A longitudinal study involving 121 patients diagnosed with HCM.
  • Assessment of depressive symptomatology using the Beck Depression Inventory and the Center for Epidemiological Studies Depression Scale (CES-D).
  • Structured Clinical Interview for DSM-III/DSM-III-R used for interviews; statistical analysis performed using SPSS.

Main Results:

  • Patients with HCM exhibit higher rates of depression compared to the general population.
  • No significant positive correlation was found between depressive symptoms and the risk factors for sudden death in HCM patients.
  • Patients identified as high-risk for sudden death did not report more severe depressive symptoms than lower-risk patients.
  • The duration of the cardiac disease diagnosis was not associated with the presence or severity of depressive symptoms.

Conclusions:

  • Depressive symptoms are more prevalent in patients with HCM than in the general population.
  • Depressive symptoms and sudden death risk factors appear to be independent in HCM patients.
  • Routine screening for mood disorders in HCM patients is recommended for early diagnosis and psychiatric treatment.
Abstract

Keywords:
Hypertrophic cardiomyopathyanxietycardiomyopathy hypertrophicdepressionpsychology/psychiatryrisk factorssudden death

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.4K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.6K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
636
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
653
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.5K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.2K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
753
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
591