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Related Experiment Video

Updated: Mar 19, 2026

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Published on: July 21, 2021

Symmetric BMPs on the Developmental Road.

Svetlana Gavrilov¹, Elizabeth Lacy¹

¹Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA.

Developmental Cell

|June 22, 2016

Summary

Bilaterally symmetrical Bone Morphogenetic Protein (BMP) signaling is essential for aligning dorsal and ventral midline structures during vertebrate development. This study reveals BMP

Area of Science:

Developmental Biology
Molecular Biology
Cellular Biology

Background:

Vertebrate development involves complex processes to align midline structures.
The precise signaling pathways and cellular mechanisms governing this alignment are not fully understood.

Purpose of the Study:

To investigate the role of signaling pathways in coordinating dorsal and ventral tissue morphogenesis.
To elucidate the cellular mechanisms underlying midline structure alignment.

Main Methods:

Analysis of gene expression patterns.
Cellular imaging techniques.
Functional assays in developmental models.

Main Results:

Identified a critical role for bilaterally symmetrical Bone Morphogenetic Protein (BMP) signaling.

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Related Experiment Videos

Last Updated: Mar 19, 2026

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Published on: July 21, 2021

In Vivo Modeling of the Morbid Human Genome using Danio rerio

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

Demonstrated BMP signaling's involvement in coordinating dorsal and ventral tissue morphogenesis.

Provided insights into the cellular basis of midline alignment.

Conclusions:

Bilaterally symmetrical BMP signaling is a key regulator of dorsal-ventral midline alignment.
This finding advances our understanding of fundamental vertebrate developmental processes.
Highlights the importance of symmetrical signaling in tissue patterning.