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DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in

Kohinoor Kaur1, Priyanka Kumari1, Saurabh Sharma1

  • 1Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.

The FEBS Journal
|June 22, 2016
PubMed
Summary

Mycobacterium tuberculosis DevS is a bifunctional sensor that regulates the DevR dormancy regulon. Its kinase activity is activated by hypoxia, while its phosphatase activity prevents gene expression under aerobic conditions, controlling bacterial dormancy.

Keywords:
DevR/DosRDevS/DosSMycobacterium tuberculosisdormancy regulonhistidine kinasephosphatase

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