Related Experiment Videos
Lithium alters the stereoselectivity of monoamine oxidase in rat brain
1Aarhus University Institute of Psychiatry, Psychiatric Hospital, Risskov, Denmark.
Journal of Neural Transmission
|January 1, 1989
Abstract:
The effects of lithium on monoamine oxidase (MAO) in rat brain were studied in the presence of each enantiomer of tranylcypromine [(+)- and (-)-TCP]. The (+)-enantiomer was 25 times more potent than its antipode as MAO inhibitor. Lithium enhanced the inhibitory effect of (-)-TCP on MAO, but it did not affect actions of the (+)-enantiomer. Moreover, lithium influenced the stereoselective index for MAO, which suggests that lithium altered conformational features of the enzyme.