Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Class II HLA antigens in multiple sclerosis.

D H Miller1, R W Hornabrook, J Dagger

  • 1Department of Medicine, Wellington Hospital, New Zealand.

Journal of Neurology, Neurosurgery, and Psychiatry
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurements of the exclusive decays of the upsilon(5S) to meson final states and improved B(s)* mass measurement.

Physical review letters·2006
Same author

Charmonium Decays of Y(4260), psi(4160), and psi(4040).

Physical review letters·2006
Same author

Observation of Psi(3770)-->gammachi(c1)-->gammagammaJ/Psi.

Physical review letters·2006
Same author

MRI T2 lesion burden in multiple sclerosis: a plateauing relationship with clinical disability.

Neurology·2006
Same author

Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis.

Brain : a journal of neurology·2006
Same author

Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis.

Journal of neurology·2006
Same journal

Global epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

Journal of neurology, neurosurgery, and psychiatry·2026
See all related articles

Human Leukocyte Antigen (HLA) typing shows a strong link between DR2 and multiple sclerosis (MS) risk in Caucasian populations. This finding suggests DR2 is a significant genetic risk factor for developing MS.

Area of Science:

  • Immunogenetics
  • Neurology
  • Human Leukocyte Antigen (HLA) research

Background:

  • Multiple sclerosis (MS) is a complex neurological disease with a known genetic component.
  • Human Leukocyte Antigen (HLA) genes are critical for immune system regulation and have been implicated in autoimmune diseases like MS.

Purpose of the Study:

  • To investigate the association between specific HLA antigens and susceptibility to multiple sclerosis (MS).
  • To clarify the relationship between HLA-DR2, HLA-DQw1, and MS risk in the Wellington population.

Main Methods:

  • Performed HLA typing on individuals in Wellington.
  • Analyzed the association between specific HLA antigens (DR2 and DQw1) and the incidence of multiple sclerosis.

Main Results:

Related Experiment Videos

  • A stronger association was observed between HLA-DR2 and multiple sclerosis compared to HLA-DQw1.
  • The association with HLA-DQw1 was likely due to linkage disequilibrium with HLA-DR2.

Conclusions:

  • HLA-DR2 is identified as a significant risk factor for multiple sclerosis in Caucasoid populations.
  • The findings support a multifactorial model for MS susceptibility, involving multiple genetic risk factors.