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Clinical experience with ofloxacin (DL-8280) in the therapy of various infections
P Cristiano1, M R Iovene, G Morelli
1Institute of Internal Medicine, 1st Medical School, Naples University, Italy.
Abstract:
Thirty-four hospitalized patients with various infections: 19 with typhoid fever, 4 with gastroenteritis, 7 with lower respiratory tract infections, 2 with biliary tract infections, 1 with brucellosis and 1 with infection of necrotic ulceration of the feet, were treated with ofloxacin at a daily dosage ranging between 600 and 900 mg orally. Thirty-one of 34 patients (91.18%) completely recovered and pathogens were eradicated. In 2 patients, both with respiratory tract infections, the treatment failed and in one patient, affected by infection of necrotic ulcerations of the feet, improvement was registered. No side effects were recorded. Ofloxacin can be considered a safe and effective antimicrobial agent in the therapy of these infections.
Insights
Ofloxacin effectively treated various infections in hospitalized patients, achieving a 91.18% recovery rate with no side effects. This study highlights ofloxacin
Area of Science:
- Infectious Diseases
- Pharmacology
Background:
- Hospitalized patients present diverse infections requiring effective antimicrobial therapy.
- Fluoroquinolones, such as ofloxacin, are broad-spectrum antibiotics used for various bacterial infections.
Purpose of the Study:
- To evaluate the efficacy and safety of ofloxacin in treating a range of infections in hospitalized patients.
- To determine the clinical outcomes and side effect profile of oral ofloxacin therapy.
Main Methods:
- A cohort of 34 hospitalized patients with infections including typhoid fever, respiratory, and biliary tract infections were treated with ofloxacin.
- Oral ofloxacin was administered at daily dosages ranging from 600 to 900 mg.
- Clinical recovery, pathogen eradication, and adverse events were monitored.
Main Results:
- Of 34 patients, 31 (91.18%) achieved complete recovery with pathogen eradication.
- Treatment failure occurred in 2 patients with respiratory tract infections.
- One patient with necrotic ulcer infection showed improvement, and no side effects were reported.
Conclusions:
- Ofloxacin demonstrates high efficacy and safety as an oral antimicrobial agent for treating diverse infections in hospitalized patients.
- The study supports the use of ofloxacin in managing conditions like typhoid fever and respiratory tract infections.
- Further research may explore ofloxacin's role in complex or resistant infections.