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Related Experiment Videos

Acquired monosaccharide intolerance in infants.

V N Nichols1, J K Fraley, K D Evans

  • 1U.S. Department of Agriculture, Children's Nutrition Research Center, Houston, TX 77030.

Journal of Pediatric Gastroenterology and Nutrition
|January 1, 1989
PubMed
Summary

Acquired monosaccharide intolerance (AMI) affects 9% of infants under 3 months hospitalized for diarrhea. Malnutrition is a key factor in developing AMI, with affected infants being younger and more dehydrated.

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Nutrition

Background:

  • Infants under 3 months are susceptible to gastrointestinal issues.
  • Diarrhea in infants can lead to various complications, including intolerance.
  • Acquired monosaccharide intolerance (AMI) is a concern in this age group.

Purpose of the Study:

  • To determine the incidence of AMI in hospitalized infants younger than 3 months.
  • To compare the characteristics and causes of AMI with acute diarrhea (AD) in similar infants.
  • To identify risk factors associated with the development of AMI.

Main Methods:

  • Prospective descriptive study of 555 infants (<3 months) hospitalized for diarrhea.
  • Comparison of infants with AMI to a cohort with AD.

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  • Analysis of clinical characteristics, nutritional status, and dehydration levels.

    • Main Results:

    • AMI was diagnosed in 9% of infants; 40% had other chronic diarrhea, 51% had AD.
    • Infants with AMI were younger (mean 32 days vs. 44 days), more malnourished, and more dehydrated (5% vs. 3%) upon admission.
    • Bacterial and viral causes of diarrhea were similar between groups.
    • Malnutrition was identified as a significant antecedent factor for AMI.

    Conclusions:

    • AMI occurs in 9% of young infants hospitalized with diarrhea.
    • Malnutrition, younger age, and greater dehydration are associated with AMI development.
    • Early identification and management of malnutrition may help prevent AMI in infants.