Related Experiment Video
Updated: Mar 19, 2026

Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
Published on: May 21, 2018
Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation
Yuki Hirota-Takahata1, Shiho Kozuma2, Nahoki Kuraya2
1Organic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan.
Abstract:
In the course of our screening program for inhibitors of lipopolysaccharide binding to cellular receptor CD14, a potent inhibitory activity was detected in the cultured broth of Pseudoalteromonas sp. SANK 71903. Four active compounds, ogipeptins A, B, C and D, were isolated from the cultured broth. The structures of these compounds were elucidated by physicochemical data and spectral analyses, and they were determined to be new cyclic lipopeptides.
Related Concept Videos
Formation of Lipopolysaccharides
Inhibitors of Gram-positive Cell Wall Synthesis

