Related Experiment Video
Updated: Mar 19, 2026
08:00
Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
Published on: April 11, 2018
11.2K
Paediatric nasal polyps in cystic fibrosis
Mohd Afiq Mohd Slim1, David Dick1, Keith Trimble1
1Department of Ear, Nose and Throat, Royal Victoria Hospital, Belfast, UK.
BMJ Case Reports
|June 23, 2016
Summary
Cystic fibrosis (CF) patients often develop nasal polyps. This case highlights functional endoscopic sinus surgery (FESS) providing symptom relief and improved facial appearance in a young CF patient with nasal polyposis.
Area of Science:
- Otolaryngology
- Pediatric Pulmonology
- Medical Genetics
Background:
- Cystic Fibrosis (CF) is a genetic disorder increasing the risk of sinonasal complications, including nasal polyposis.
- Nasal polyps in CF patients can lead to significant upper airway obstruction and facial deformities.
- The efficacy of early surgical intervention for CF-related nasal polyposis remains debated.
Observation:
- A 17-month-old child with CF presented with hypertelorism, astigmatism, nasal discharge, and noisy breathing.
- Imaging revealed bilateral ethmoid mucoceles.
- Surgical findings included bilateral soft tissue masses obstructing the nasal cavity.
Findings:
- Histological examination confirmed inflammatory nasal polyposis characteristic of CF.
- The patient underwent polypectomy and bilateral mega-antrostomies.
- Post-operative assessment showed significant relief of upper airway symptoms and normalization of facial appearance.
Implications:
- This case suggests potential benefits of functional endoscopic sinus surgery (FESS) for symptom management in pediatric CF patients with nasal polyposis.
- While recurrence rates are a concern, FESS may improve quality of life and cosmetic outcomes.
- Further research is needed to define the optimal surgical timing and long-term impact of FESS in this population.
Related Concept Videos
01:23Cystic Fibrosis: Pathogenesis
1.0K
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.0K
01:24Cystic Fibrosis: Management
605
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
605
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
1.5K
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
1.5K
01:29Suctioning the Nasopharyngeal Airway
4.8K
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
4.8K