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Nucleus accumbens hyperpolarization-activated cyclic nucleotide-gated channels modulate methamphetamine

Dan-Ni Cao1, Rui Song1, Shu-Zhuo Zhang1

  • 1State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing, 100850, China.

Psychopharmacology
|June 23, 2016
PubMed
Summary

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the nucleus accumbens are crucial for methamphetamine addiction. Blocking these channels reduces drug reinforcement and motivation, offering potential therapeutic targets for addiction treatment.

Keywords:
DopamineHyperpolarization-activated cyclic nucleotide-gated channelsIn vivo microdialysisMethamphetamineNucleus accumbensSelf-administration

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