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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Additive Prognostic Value of Left Ventricular Systolic Dysfunction in a Population-Based Cohort
Tatiana Kuznetsova1, Nicholas Cauwenberghs2, Judita Knez2
1From the Research Unit Hypertension and Cardiovascular Epidemiology (T.K., N.C., J.K., W.-Y.Y., L.T., J.A.S.), the Division of Cardiovascular Imaging and Dynamics (L.H., J.D.), and the Division of Cardiology (J.-U.V.), KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium; and Stanford University School of Medicine, and Stanford Cardiovascular Institute, CA (F.H.). tatiana.kouznetsova@med.kuleuven.be.
Circulation. Cardiovascular Imaging
|June 23, 2016
Summary
Low left ventricular global longitudinal strain (GLS), measured by 2D speckle tracking, predicts cardiovascular events independently of traditional risk factors in a population-based study.
Area of Science:
- Cardiology
- Echocardiography
- Preventive Medicine
Background:
- 2D speckle tracking measures myocardial deformation (strain) during systole.
- Left ventricular global longitudinal strain (GLS) has shown prognostic value in clinical studies.
- Data on GLS and cardiovascular outcomes in the general population are limited.
Purpose of the Study:
- To investigate if GLS provides additional prognostic information beyond traditional cardiovascular risk factors.
- To assess the association between GLS and cardiovascular outcomes in a large, population-based cohort.
Main Methods:
- GLS was measured using 2D speckle tracking in 791 participants.
- Multivariable hazard ratios were calculated for midwall, endocardial, and epicardial GLS.
- Follow-up was a median of 7.9 years.
Main Results:
- Midwall, endocardial, and epicardial GLS were significant predictors of cardiovascular and cardiac events.
- Low midwall GLS (<18.8% in women, <17.4% in men) was associated with significantly higher risk for cardiovascular and cardiac events.
- Increased cardiovascular event risk correlated with the number of left ventricular abnormalities, including low GLS, diastolic dysfunction, and hypertrophy.
Conclusions:
- Low GLS, assessed by 2D speckle tracking, independently predicts future cardiovascular events.
- Left ventricular midwall strain is a simple echocardiographic measure for cardiovascular risk assessment in population-based cohorts.
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